منابع مشابه
Carbon-fluorine bond formation.
A selection of carbon-fluorine bond-forming reactions that have been developed in the recent past are presented. An overview of the most common fluorination reagents is followed by descriptions of fluorination reactions that are organized by reactivity. The distinction between nucleophilic and electrophilic fluorinations is highlighted, as well as between aliphatic and aromatic fluorinations. E...
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The action of horseradish peroxidase on p-fluoroaniline was the first enzyme-dependent cleavage of the carbon-fluorine bond to be described (1). Other apparently adventitious cleavages of this relatively stable chemical bond are catalyzed by several mixed function oxidases. These include the action of a phenylalanine-hydroxylating system on p-fluorophenylalanine (2) and the action of an aniline...
متن کاملCarbon-carbon bond cleavage in activation of the prodrug nabumetone.
Carbon-carbon bond cleavage reactions are catalyzed by, among others, lanosterol 14-demethylase (CYP51), cholesterol side-chain cleavage enzyme (CYP11), sterol 17β-lyase (CYP17), and aromatase (CYP19). Because of the high substrate specificities of these enzymes and the complex nature of their substrates, these reactions have been difficult to characterize. A CYP1A2-catalyzed carbon-carbon bond...
متن کاملSulfur - fluorine bond in PET radiochemistry
The importance of the sulfur-fluorine bond is starting to increase in modern medicinal chemistry literature. This is due to a better understanding of the stability and reactivity of this moiety depending on the various oxidation states of sulfur. Furthermore, several commercial reagents used for mild and selective fluorination of organic molecules are based on the known reactivity of S-F groups...
متن کاملAsymmetric [3+ 2] cycloaddition of donor–acceptor aziridines with aldehydes via carbon–carbon bond cleavage
An enantioselective [3 + 2] annulation of donor–acceptor aziridines with aldehydes has been realized using a Nd(OTf)3/N,N0-dioxide/LiNTf2 catalyst system, providing various chiral cis-1,3-oxazolidines inmoderate to good yields with high levels of stereocontrol. A relay catalytic process is proposed where LiNTf2 promotes the formation of azomethine ylide intermediates, and a chiral Nd(III)–N,N0-...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1966
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(18)96379-9